Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 1 ML
Ceftolozane TFA is a cephalosporin-class antibiotic supplied as a 10 mM solution in DMSO (1 mL). It is intended for use in antibacterial research, analytical method development, and as a building block for synthesis of novel antibiotics. Trifluoroacetate salt; molecular formula C25H31F3N12O10S2; molecular weight 780.71 g/mol.
- Provided as a ready-to-use 10 mM solution in DMSO.
- Suitable for antibacterial activity assays and analytical method development.
- Useful as a synthetic intermediate and reference standard for research.
- High purity suitable for analytical and preparative applications.
- Supplied in a 1 mL vial for small-scale experiments.
Medchemexpress LLC Bibo3304 trifluoroacetate | 191868-14-1 | MFCD04112989 | 100.0% | 643.66 g·mol⁻¹ | C31H36F3N7O5 | 10 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used in pharmacological and receptor biology research. Supplied as a trifluoroacetate salt in solid form, it is characterized by a defined molecular formula and molecular weight and is intended for in vitro and in vivo experimental applications.
- Potent NPY Y1 receptor antagonist with subnanomolar affinity.
- High reported purity suitable for research-grade assays.
- Stable solid trifluoroacetate salt for convenient handling and storage.
- Available in small milligram quantities and pre-made DMSO solutions for assay readiness.
- Characterized molecular weight and formula to support analytical and dosing calculations.
Medchemexpress LLC Ceftolozane trifluoroacetate salt | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 25 MG
Ceftolozane TFA is the trifluoroacetate salt of ceftolozane, a cephalosporin-class antibiotic active against Gram-negative bacteria. It is provided for research use in antibacterial studies, assay development, and medicinal chemistry where it can serve as a synthetic intermediate for the design and optimization of novel antibiotic candidates.
- Trifluoroacetate salt form for improved stability and handling.
- Active against Gram-negative bacteria.
- Suitable for medicinal chemistry and synthetic applications.
- Available in small research quantities for assay development.
- Characterized with confirmed purity and molecular weight.
Apexbio Technology LLC COG 133 TFA 2828432-37-5 1mg
COG 133 TFA (CAS 2828432-37-5) is a peptide fragment derived from apolipoprotein E (APOE) that competitively binds to low-density lipoprotein receptors modulating associated signaling pathways This compound exhibits both anti-inflammatory and neuroprotective properties with an antagonist activity concentration of 445 nM reported in relevant assays Owing to its specific mechanism of action and demonstrated biological effects COG 133 TFA is widely utilized in research focused on neurodegenerative disorders and inflammation-related pathologies
Medchemexpress LLC MM-102 trifluoroacetate | 1883545-52-5 | 99.7% | 2 MG
MM-102 TFA is the trifluoroacetate salt of MM-102, a research reagent that inhibits the WDR5/MLL protein-protein interaction. It is supplied as high-purity solid and as DMSO solution formats for biochemical and cellular studies, with reported potency in WDR5 binding assays.
- Potent inhibitor of the WDR5/MLL protein-protein interaction.
- Reported IC50 = 2.4 nM in WDR5 binding assay.
- High reported purity (99.68%).
- Available in small solid quantities and as 10 mM in DMSO solution.
- Trifluoroacetate salt form for convenient handling and solubility.
Medchemexpress LLC Galnon TFA | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 | C42H47F3N4O8 | 5 MG
Galnon TFA is a selective, non-peptide agonist of galanin receptors GAL1 and GAL2 used in neuroscience research. It binds GAL1 and GAL2 with reported Kis of 11.7 μM and 34.1 μM and has demonstrated anticonvulsant and anxiolytic effects. The compound is supplied as a white to off-white solid with high purity and is soluble in DMSO for in vitro use.
- Selective galanin receptor agonist (GAL1 and GAL2).
- Demonstrated anticonvulsant and anxiolytic activity in preclinical models.
- High purity (98.9%) and white to off-white solid appearance.
- Soluble in DMSO (125 mg/mL); use fresh DMSO and ultrasonic assistance if needed.
- Recommended storage sealed, protected from moisture and light; frozen solution stability varies by temperature.