Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Aqp4 (201-220) Tfa | 99.9% | 2151.40 | 5 MG
Aqp4 (201-220) Tfa | 99.9% | 2151.40 | 5 MG
Medchemexpress LLC Rf470 TFA | 2369899-34-1 | 624.63 | 25 MG
Rf470 TFA is a FMR-probe-D-lysine conjugate (Max Ex: 470 nM; Max Em: 640 nM) that can be covalently incorporated into peptidoglycan by bacteria. It exhibits extremely weak fluorescence in its free state, but its fluorescence significantly increases when it is catalytically incorporated into peptidoglycan by transpeptidases.
- Can be used for real-time monitoring of peptidoglycan biosynthesis.
- Can be used for detection of transpeptidase activity.
- Can be used for screening of antibiotics through fluorescence changes.
Medchemexpress LLC T-Boc-Met-Asp-Gly-Cys-Glu-Leu | 99.2% | 880.90 | 1 MG
Box5 TFA is a potent Wnt5a antagonist. It inhibits Wnt5a signaling and Wnt5a-mediated Ca2+ release, and also inhibits cell migration. It has the potential for the research of melanoma.
- In vitro: decreases the expression of rWnt5a (0.1 μg/mL) stimulated p-MARCKS in A2058 cells.
Strem, An Ascensus Company CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
Medchemexpress LLC HR97 TFA | 1518.84 | 5 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops HR97-SunitiGel. The peptide-drug conjugate in HR97-SunitiGel can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Molecular weight of 1518.84 (free acid)
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Solubility in DMSO: 50 mg/mL (requires ultrasonic)
- Can be used to prepare HR97-SunitiGel eye drops
Medchemexpress LLC Nls-Stax-h (Tfa) | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
Nls-Stax-h is a selective, cell-permeable, stapled peptide that acts as a Wnt signaling inhibitor. It has an Ic50 of 1.4 μM and effectively inhibits β-catenin-transcription factor interactions. This compound demonstrates anti-proliferative effects on cancer cells.
- Selective Wnt signaling inhibitor.
- Cell-permeable.
- Stapled peptide.
- Inhibits β-catenin-transcription factor interactions.
- Shows anti-proliferation of cancer cells.
- Inhibits proliferation of colorectal cancer cells at 10 μM over 72 h, reducing viability by more than 80% in SW-480 and DLD-1 cells.
- Inhibits migration of colorectal cancer cells at 5 and 10 μM over 24 h, resulting in dose-dependent inhibition of wound closure (52% at 5 μM, and 24% at 10 μM in DLD-1 cells).
Medchemexpress LLC DX600 TFA | 99.2% | 3074.33 (free acid) | 1 MG
DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been observed to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity. It is for research use only.
- Selective ACE2 specific inhibitor
- Does not cross-react with ACE
- Exacerbates diabetes-induced cardiovascular dysfunction
- Increases cardiac and renal NOX activity
Medchemexpress LLC Hr97 Tfa | 1518.84 | 1 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops called HR97-SunitiGel. The peptide-drug conjugate can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Combines with engineered melanin to prepare eye drops
- Supports sustained ocular drug delivery
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Shortened sequence: FSGKRRKRKPRC
- In vitro solubility: 50 mg/mL in DMSO (need ultrasonic)
Medchemexpress LLC Biotin-COG1410 TFA | 98.0% | 1 MG
Biotin-COG1410 TFA is a biotin-labeled COG1410. COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. It exerts neuroprotective and anti-inflammatory effects in a murine model of traumatic brain injury (TBI) and can be used for the research of neurological diseases.
- Decreases the production and release of NO and TNFα in BV2 microglia cells.
- Exhibits significant improvement on vestibulomotor function and spatial learning and memory in mice.
- Improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats.
Medchemexpress LLC Clovibactin TFA | 97.1% | 903.08 | 100 UG
Clovibactin TFA is the TFA salt form of Clovibactin. It is an antibiotic effective against drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inhibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors.
- Effective against drug-resistant bacterial pathogens
- Exhibits no detectable resistance
- Inhibits cell wall synthesis
- Targets pyrophosphate of peptidoglycan precursors
Medchemexpress LLC F11R peptide TFA | 97.6% | 1459.58 | 5 MG
F11R peptide TFA is an F11 receptor molecule that inhibits anti-F11R antibody-induced platelet aggregation and the adhesion of platelets to cytokine (TNFα and INF-γ)-inflamed endothelial cells. It can be used for research of atherosclerotic plaques and associated thrombotic disease.
- Inhibits anti-F11R antibody-induced platelet aggregation.
- Inhibits the adhesion of platelets to cytokine (TNFα and INF-γ)-inflamed endothelial cells.