Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 1 ML
Ceftolozane TFA is a cephalosporin-class antibiotic supplied as a 10 mM solution in DMSO (1 mL). It is intended for use in antibacterial research, analytical method development, and as a building block for synthesis of novel antibiotics. Trifluoroacetate salt; molecular formula C25H31F3N12O10S2; molecular weight 780.71 g/mol.
- Provided as a ready-to-use 10 mM solution in DMSO.
- Suitable for antibacterial activity assays and analytical method development.
- Useful as a synthetic intermediate and reference standard for research.
- High purity suitable for analytical and preparative applications.
- Supplied in a 1 mL vial for small-scale experiments.
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 100G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 100G
Medchemexpress LLC Mm-102 trifluoroacetate | 1883545-52-5 | 99.7% | 1 ML
MM-102 TFA is the trifluoroacetate salt of MM-102, a potent inhibitor of the WDR5/MLL protein-protein interaction, supplied as a ready-to-use 10 mM solution in DMSO for research applications.
- Potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM).
- Supplied as a 10 mM solution in DMSO, 1 mL volume.
- High purity listed at 99.68% (reported as 99.7%).
- Molecular weight 783.83 g·mol⁻1; formula C37H50F5N7O6.
- For research use only; not for human or clinical use.
Medchemexpress LLC Ezm0414 Tfa | 2411759-92-5 | 95.5% | 514.51 | 25 MG
EZM0414 TFA is the trifluoroacetate salt form of EZM0414. It functions as a potent, selective, and orally active inhibitor of SETD2, making it suitable for research applications. This compound is being investigated for its potential in treating relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- TFA salt form of EZM0414.
- Potent, selective, orally active SETD2 inhibitor.
- IC50 of 18 nM in biochemical assay.
- IC50 of 34 nM in cellular assay.
- Appearance is solid, white to light yellow.
- Store at 4°C, sealed, away from moisture.
- When in solvent, store at -80°C for 2 years or -20°C for 1 year, sealed and away from moisture.
Sigma Aldrich Fine Chemicals Biosciences TRIFLUOROACETIC ACID 100ML
NC3241523 TRIFLUOROACETIC ACID 100ML
Medchemexpress LLC UNC8732 TFA | 2929304-06-1 | 99.1% | 723.74 | 5 MG
UNC8732 TFA is a potent NSD2 inhibitor and degrader, designed for use in research applications. This compound plays a crucial role in studying protein degradation pathways.
- Acts as a NSD2 inhibitor.
- Functions as a protein degrader.
- Suitable for various research applications.
Medchemexpress LLC T-Boc-Met-Asp-Gly-Cys-Glu-Leu | 99.2% | 880.90 | 1 MG
Box5 TFA is a potent Wnt5a antagonist. It inhibits Wnt5a signaling and Wnt5a-mediated Ca2+ release, and also inhibits cell migration. It has the potential for the research of melanoma.
- In vitro: decreases the expression of rWnt5a (0.1 μg/mL) stimulated p-MARCKS in A2058 cells.
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 5 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein.
- Appearance: Solid
- Color: White to off-white
- Sequence: Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
- Shipping: Room temperature in continental US
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light, under nitrogen)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light, under nitrogen)
- Solubility (H2O): 100 mg/mL (needs ultrasonic)
- Solubility (DMSO): ≥ 100 mg/mL
- Related classifications: Peptides, Peptide and derivatives, Peptides for drug delivery, Cell-penetrating peptides
- Disease areas: Infection, Anti-infection HIV
Medchemexpress LLC DAMGO TFA | 950492-85-0 | 99.5% | 627.61 | 25 MG
DAMGO TFA is a selective agonist for the μ-opioid receptor (μ-OPR) with a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, without down-regulating CXCR4 protein expression. It is for research use only.
- Effectively inhibits prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa).
- Produces significant anti-injury effects.
- Exhibits long-lasting analgesic effects in a dose-dependent manner.
Medchemexpress LLC Guangxitoxin 1E TFA | ≥95.0% | 3948.61 | 100 UG
Guangxitoxin 1E TFA is the trifluoroacetate salt form of Guangxitoxin 1E, a peptide toxin. It functions as a potent and selective blocker of voltage-gated potassium channels KV2.1 and KV2.2, with an IC50 of 1-3 nM. This compound is intended for research purposes only and is not for human therapeutic use.
- Potent and selective blocker of KV2.1 and KV2.2 channels (IC50 of 1-3 nM)
- Inhibits KV4.3 channels (IC50 of 24-54 nM)
- Inhibits 90% of IDR in mouse β-cells
- Shifts voltage dependence of channel activation to more depolarized potentials
- Broadens β-cell action potential
- Enhances glucose-stimulated intracellular calcium oscillations
- Increases insulin secretion from mouse pancreatic islets in a glucose-dependent manner
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 | 5 MG
FLAG peptide TFA is the trifluoroacetic acid salt form of FLAG peptide, often denoted as HY-P0223. It functions as a versatile fusion tag specifically designed for the purification of recombinant proteins. This peptide plays a crucial role in maintaining the natural, functional folding of the proteins it is fused with, ensuring their biological activity. It can be efficiently removed by enterokinase and is capable of being eluted under non-denaturing conditions, which is beneficial for preserving protein integrity.
- Multifunctional fusion tag
- Used for purification of recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 1mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo500G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo500G
Medchemexpress LLC MM-401 TFA | 1442106-11-7 | 99.3% | 700.75 | 1 MG
MM-401 (TFA) is an MLL1 H3K4 methyltransferase inhibitor. It inhibits MLL1 activity with an IC50 of 0.32 μM by blocking the MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis, and differentiation and can be used for research into MLL leukemia.
- Target specificity: Inhibits MLL1 H3K4 methyltransferase activity by blocking MLL1-WDR5 interaction.
- Potency: Inhibits MLL1 activity with an IC50 of 0.32 μM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM.
- Cellular effects: Induces cell cycle arrest, apoptosis, and differentiation.
- Research application: Useful for research of MLL leukemia.
- Purity: 99.34%.